Niacin (vitamin B3) occurs in the body as two metabolically active coenzymes, NAD (nicotinamide adenine dinucleotide) and NADP (NAD phosphate). The niacin coenzymes NAD and NADP play important roles in energy-related and biosynthetic metabolic processes. At least 200 enzymes depend on these niacin cofactors.

The NAD-dependent enzymes are involved in mostly catabolic, oxidative reactions that release energy from carbohydrate, fat, and protein, whereas the NADP-dependent enzymes are more commonly involved in the biosynthesis of compounds like fatty acids and steroid hormones.

Independent of its functions as NAD or NADP, niacin is also involved in the regulation of normal blood lipoprotein and cholesterol levels, and in the maintenance of normal vascular tone.

Dietary niacin is generally well absorbed and taken up by the liver. Any excess niacin is metabolized by the liver and excreted by the kidneys, but because the liver has a limited capacity to metabolize niacin, high doses of regular, crystalline niacin are known to cause vasodilatory side effects known as skin-flushing and itching. These niacin supplement tablets contain inositol hexaniacinate, an ester of niacin and inositol that eliminates the skin-flushing side effects that are sometimes felt and observed with high-dose crystalline niacin.

Niacinate tablets may be a useful dietary supplement for individuals who wish to increase their intake of niacin without the side effects of skin flushing.

Serving Size: 1 tablet, 1-3 times daily with meals

Servings Per Container: 90

Ingredients: Niacin (as inositol hexaniacinate) 505 mg, inositol (from inositol hexaniacinate) 115 mg

Other ingredients: Dicalcium phosphate, cellulose, stearic acid, vegetable stearate, silica